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A group of Harvard and MIT students have created a lung cancer breathalyzer system

MIT lung cancer breathalyzer
Graham Lieberman, Jay Kumar, Alexander Blair, and Joseph Azzarelli of Astraeus Technologies accept their $100,000 grand prize from MIT. Michael Last/MIT
Today’s connotation of a breathalyzer test isn’t exactly the most positive: Did you blow beneath a 0.08? Great. But all that could soon change thanks to a team of entrepreneurs from Harvard University and the Massachusetts Institute of Technology. Taking the concept of the dreaded test to anticipate rather than test for dangerous situations, a group of students have developed a breathalyzer capable of detecting early stages of lung cancer. Earlier this week at MIT’s 27th annual Entrepreneurship Competition, Astraeus Technologies won a $100,000 grand prize for its L CARD (Chemically Actuated Resonate Device), a postage stamp-sized device capable of detecting certain gases that could indicate the presence lung cancer.

The device works just like a traditional breathalyzer, requiring users to blow on its sensor. But what happens after is very different indeed: A companion mobile app will turn a smartphone screen red should the device detect suspicious gases, and green in their absence.

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In demonstrations, inventor Joseph Azzarelli, an MIT doctorate student in chemistry, showed how the breathalyzer reacted to a spray from a syringe of lung cancer-signaling gases onto the device. The smartphone screen turned red. “The L CARD reacts and sends instantaneous information to the physician that further attention is required,” Azzarelli said.

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The L CARD picks up on specific volatile organic compounds that science has shown are uniquely present in lung cancer patients. These compounds modify the L CARD’s radio frequency identification signal, and this signal tells the smartphone whether to turn red or green.

Jay Kumar, a student at Harvard Medical School, says that these devices are about 10 times more accurate than CT scans, and are incredibly cheap to boot. While CT scans cost about $800 a pop, this breathalyzer requires less than $1 to make, and Astraeus plans to sell the L CARDS directly to hospitals for use in regular exams.

“We’re going after lung cancer,” Kumar said. “The root cause is bad screening: We’ve developed a better screening test, and it’s cost effective.”

The team says that it plans on using its $100,000 in prize money for product development and first-round clinical trials in area hospitals.

Lulu Chang
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